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Category: Transcription factors and their control

Name	Function
bceR	resistance against toxic peptides
cheY	modulation of flagellar switch bias
citT	regulation of citrate uptake
comA	regulation of genetic competence and quorum sensing
cssR	control of cellular responses to protein secretion stress
dctR	regulation of the [gene\|9A96572B101358768EB20EE9438BE0E1424A4130\|dctS]-[gene\|97C34F6FA0B89D93369150E9A8AB3579332B07BC\|dctR]-[gene\|search\|dctP ]operon
degU	regulation of degradative enzymes, [SW\|genetic competence], and other adaptive responses
desR	regulation of cold shock expression of [gene\|644C0C354B72FC07222EE45F4D2E0E57434B5EB5\|des]
glnL	regulation of the glsA-glnT operon
liaR	regulation of the [gene\|B6D1159454969D1D578E05D5CE2259E079688510\|liaI]-[gene\|AE4BF12C368468C553EED7A696D5EFC63F56CA39\|liaH]-[gene\|A71B0392FFF70EFFC096E7E9BD5FE30792821CDD\|liaG]-[gene\|C107A958DFA2B0DA4837E2F9F648CD329A3116AC\|liaF]-[gene\|9A1871BD853254EEA8B4E78CA187F9315CBDF43D\|liaS]-[gene\|search\|liaR ]operon
lnrK	resistance to linearmycin
lytT	control of pyruvate utilization
malR	regulation of malate uptake
natR	regulation of the [gene\|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936\|natA]-[gene\|search\|natB ]operon
phoP	regulation of phosphate metabolism ([gene\|E0430C16C41440633647976A0F9183E24268E198\|phoA], [gene\|3B95AB3021280215B6B487A348D78FB5797AEEA6\|phoB], [gene\|597771E2E8EC31ED9B2CC8C0E4D888DEEA80F689\|phoD], [gene\|F7D869F77E2275110737EF658C58FA1BF742D73F\|resABCDE], [gene\|72A89412C53703F96F835D26307263F5D1A4AB4E\|tagA]-[gene\|911A4D957A6C0DFC636A152395119DBFC777DDA2\|tagB], [gene\|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C\|tagDEF], [[gene\|tuaA\|tuaA-H]])
psdR	resistance against toxic peptides
resD	regulation of aerobic and anaerobic respiration
spo0A	initiation of [SW\|sporulation]
walR	control of cell wall metabolism
ybdJ	unknown
ycbL	unknown
yclJ	unknown
ydfI	control of [gene\|search\|ydfJ ]expression
yesN	unknown
yhcZ	unknown
ykoG	unknown
yneI	unknown
yrkP	unknown
yvfU	unknown
yvrHb	regulation cell surface maintenance
yxdJ	resistance against toxic peptides
yxjL	unknown

Key publications

30008469,31100988

3.4.2.2. Control of two-component response regulators

Key publications

30008469

3.4.2.3. PRD-type regulators

Name	Function
glcT	control of glucose uptake
levR	regulation of levan and fructose utilization
licR	regulation of lichenan utilization
licT	control of beta-glucan and beta-glucoside utilization
manR	regulation of mannose utilization
mtlR	regulation of mannitol utilization
sacT	regulation of sucrose utilization
sacY	regulation of sucrose utilization

Key publications

9663674,31100987

3.4.2.4. Control of PRD-type regulators

Name	Function
bglP	beta-glucoside uptake and phosphorylation, control of [protein\|search\|LicT ]activity
levE	fructose uptake and phosphorylation, control of [protein\|1D2043CC0D8CF64142F0A5993A936C5A196726D4\|LevR] activity
licB	lichenan uptake and phosphorylation, control of LicR activity
manP	mannose uptake and phosphorylation, control of [protein\|F273002AF97D87BB025B4F014C328C5592EAD621\|ManR] activity
mtlA	mannitol uptake and phosphorylation, control of [protein\|1CEDC98C9EDD8F3DEA0AF4B2104DA1BF86E688C2\|MtlR] activity
ptsG	glucose transport and phosphorylation, control of [protein\|BC0DF593AE969F1DBC5E9E2BACF1C00BE4FEE449\|GlcT] activity
sacP	sucrose uptake and phosphorylation, control of [protein\|6796E1C147AA21E919A42A953884DC24E182F430\|SacT] activity
sacX	sucrose uptake and phosphorylation, control of [protein\|EB330AB3DC6C8C3EC72C4CAFA2BC59CC485EE344\|SacY] activity

3.4.2.5. Transcription factors/ other

Name	Function
acoR	regulation of acetoin utilization
adaA	adaptive response to alkylative DNA damage
adeR	control of [gene\|2D346CF412BA32EE18111DA930CFA1306F95024B\|ald] expression
adhR	regulation of the protective response to formaldehyde and methylglyoxal
ahrC	transcriptional regulator of arginine metabolic genes
alaR	unknown
alsR	regulation of acetoin synthesis ([gene\|AAA45830B9C5428CADFA5551D33B513E9B1B7C8E\|alsS]-[gene\|355E70F55A28C6C2C24E8E326EFB673AC303FBEE\|alsD])
ansR	negative regulation of the [gene\|FED8E46AA1C4EFD27796D5DFBBB1663EBF336BFD\|ansA]-[gene\|search\|ansB ]operon
araR	regulation of arabinose utilization
arfM	regulation of anaerobic genes
arsR	regulation of As (III) efflux
ascR	regulation of sulphur metabolism
aseR	regulation of As (III) efflux
azlB	regulation of branched-chain amino acid transport
birA	regulation of biotin synthesis, addition of biotin to proteins
bkdR	regulation of branched-chain amino acid utilization
bltR	regulation of spermidine efflux and degradation
bmrR	regulation of multidrug resistance
bsdA	regulation of resistance to salicylic acid
btr	regulation of iron acquisition
catR	resistance against oxidative and electrophile stress
ccpA	carbon catabolite repression (CCR)
ccpB	unknown
ccpC	regulation of tricarboxylic acid branch of the TCA cycle
ccpN	repressor of genes involved in gluconeogenesis ([gene\|C1B89BD3DD27CD566018558D3A7845FB451056F0\|gapB], [gene\|74D4616D1A550D87182FAAC2A4AF6E04F81E1572\|pckA]) and of [gene\|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A\|sr1]
cggR	transcriptional regulator
chrS	regulation of chromate export
citR	regulation of the minor citrate synthase
codY	regulation of a large regulon in response to branched-chain amino acid limitation
comK	regulation of [SW\|genetic competence] and DNA uptake
csoR	control of copper homeostasis
ctsR	regulation of protein degradation
cymR	regulation of sulfur metabolism
cysL	regulation of cysteine biosynthesis
czrA	regulation of resistance against toxic metal cations
deoR	regulation of deoxyribonucleotide utilization
dtrR	resistance to D-Tyr
exuR	regulation of hexuronate utilization
fadR	regulation of fatty acid degradation
fapR	regulation of fatty acid biosynthesis
fatR	unknown
fnr	regulation of anaerobiosis, fermentation and overflow metabolism
frlR	regulation of utilization of sugar amines
fruR	regulation of fructose utilization
fur	regulation of iron homoeostasis
gabR	regulation of gamma-amino butyric acid utilization
gamR	regulation of glucosamine utilization
ganR	regulation of galactan utilization
gbsR	regulation of osmoprotection
gerE	regulation of [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK]-dependent gene expression
gerR	spore coat formation and resistance of spores to lysozyme
glcR	unknown
glnR	regulation of glutamine synthesis
glpP	regulation of glycerol and glycerol-3-phosphate utilization
gltC	regulation of the glutamate synthase operon ([gene\|44DF1B7E476AD58B3CCC39300FFE0132D0D32AD0\|gltA]-[gene\|AA07CC52B2DD48ACC9D3375E9D531CB1ACBE485A\|gltB])
gltR	unknown
glvR	regulation of maltose utilization
gmuR	regulation of glucomannan utilization
gntR	regulation of gluconate utilization
gutR	regulation of glucitol utilization
hprT	purine salvage and interconversion, control of [gene\|4E7B9426CED372AA8A321A147116A3A589FBF20C\|ftsH] expression
hrcA	regulation of chaperone gene expression
hxlR	regulation of the ribulose monophosphate pathway
hypR	control of the nitroreductase gene [gene\|9DF5999568760E016ECA988385A1FA61A257D486\|hypO] in response to disulfide stress (diamide, NaOCl)
immR	control of transfer of the mobile genetic element ICEBs1
iolQ	control of scyllo-inositol utilization
iolR	regulation of myo-inositol catabolism
kdgR	regulation of galacturonic acid utilization
kipR	regulation of [SW\|sporulation] initiation
lexA	regulation of DNA damage repair
lmrA	regulation of lincomycin resistance
lrpA	repression of [gene\|BAE8062DA8538C9C83FFBA9684BECE9613EEFD2F\|glyA] transcription and [protein\|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7\|KinB]-dependent [SW\|sporulation]
lrpB	repression of [gene\|BAE8062DA8538C9C83FFBA9684BECE9613EEFD2F\|glyA] transcription and [protein\|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7\|KinB]-dependent [SW\|sporulation]
lutR	control of lactate utilization
mdtR	regulation of the multidrug-resistance [gene\|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85\|mdtR]-[gene\|search\|mdtP ]operon
melR	regulation of melibiose utilization
mgsR	controls a subset of general stress genes
mhqR	regulation of resistance to quinones and diamide
mntR	regulation of manganese transport
mta	regulation of multidrug-efflux transporter genes
mtrB	regulation of tryptophan biosynthesis(and translation) attenuation in the trp operon;repression of the folate operon
murR	regulation of muramic acid utilization
nadR	regulation of NAD biosynthesis
nagR	regulator of the [gene\|8F4D075C9B9EF995E361F9BA5E8B52F42059C422\|nagA]-[gene\|0C8D7EAC2656E989E45B5B7E42FAA6D258956B56\|nagB]-[gene\|6D36D6360FE1CBFF5F64B2A6D1406405D6C6F7D5\|nagR] operon
nrdR	control of ribonucleotide reductase expression
nsrR	repression of [protein\|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24\|ResD]-[protein\|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1\|ResE]-dependent genes in the absence of nitric oxide (NO)
ntdR	regulation of the [gene\|2F850E2DFA6287DB3890243803E06FDE7ACDB10E\|ntdA]-[gene\|A4DE6C394B64813A732255734758403241FFAC2F\|ntdB]-[gene\|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA\|ntdC]-[gene\|search\|glcP ]operon
ohrR	regulation of [gene\|869E46AECF6249610F8541E403D834284B62171D\|ohrA] expression in response to organic peroxides
opcR	regulation of choline uptake
padR	regulation of the phenolic acid stress response
paiB	regulation of sporulation, degradative enzyme and motility genes
pamR	control of the [gene\|20D50DA11B864E6C719CC34BE27C7900893EA054\|ydcF]-[gene\|89AB146F447696EF1CBE219C9A2FB5CBB380F847\|ydcG]-[gene\|search\|pamR ]operon
perR	regulation of the response to peroxide
pksA	unknown
pucR	regulation of purine utilization
purR	regulation of purine biosynthesis
putR	regulation of proline utilization
pyrR	regulation of pyrimidine biosynthesis
qdoR	control of quercetin utilization
rbsR	regulation of ribose utilization
remA	control of biofilm formation
rex	regulation of fermentation and anaerobic respiration
rghR	regulation of [SW\|sporulation ]initiation
rhaR	control of rhamnose utilization
rhgR	regulation of pectin utilization
rocR	transcriptional activator of arginine utilization operons
rok	regulation of genetic competence
scoC	transition state regulator
sdpR	regulation of protection against [protein\|820635420B3980B620F3E3D7ACF7EDE9DC6275AD\|SdpC]
senS	regulation of extracellular enzyme genes
sinR	control of [SW\|biofilm formation]
sknR	control of prophage gene expression
slrR	regulation of initiation of [SW\|biofilm formation] and of autolysis
splA	regulation of the splA-splB operon
spoIIID	regulation of mother cell gene expression
spoVT	regulation of forespore gene expression
spx	negative and positive regulator of many genes
thrR	control of threonine biosynthesis
tilS	tRNA modification, control of [gene\|4E7B9426CED372AA8A321A147116A3A589FBF20C\|ftsH] expression
tnrA	regulation of nitrogen assimilation
treR	regulation of trehalose utilization
xre	regulation of [category\|SW 5.1.1\|PBSX prophage] gene expression
xylR	regulation of xylan and xylose utilization
ycbG	regulation of glucarate/galactarate utilization
ycnK	regulation of copper uptake
yetL	regulation of [gene\|A70EA4AEBF46ED2279E8BCE8A28439078484B6E3\|yetM] expression
yfmP	regulation of the [gene\|36AF02B4EB416ABCA3F0E4C5A4126E777A20C7D1\|yfmP]-[gene\|D91356CF66ADE0CFA9E95A686DC7355B348C8B5C\|yfmO] operon
yhdQ	unknown
ykrK	regulation of membrane protein quality control
yodB	regulation of quinone and diamide detoxification
yofA	control of [gene\|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57\|ftsW] expression
yplP	required for survival at low temperatures
ytrA	control of cell envelope stress responses
ywcC	control of [gene\|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7\|slrA] expression
zur	regulation of zinc homeostasis([gene\|75DB07A2704FEC2932BD0CDD24E2B3454E9551E1\|zagA], [gene\|D33A144568CAF32FFE4A2A46BE67573DB66FC1A1\|znuA]-[gene\|6B5D4FD32CCE72C99B915B0F1EB4B8E8D42A04B3\|znuC]-[gene\|EE212953BC83BD6D69BF769D6E917F4F954BE1E2\|znuB])

3.4.2.6. Transcription factor/ other/ based on similarity

Name	Function
rmgR	unknown
whiA	control of Z ring asembly and chromosome segregation
yazB	unknown
ybfI	unknown
ybfP	unknown
ybzH	unknown
yceK	unknown
ycgE	unknown
ycgK	unknown
ycnC	unknown
ycxD	unknown
yczG	unknown
ydeB	unknown
ydeC	unknown
ydeE	unknown
ydeF	unknown
ydeL	unknown
ydeP	unknown
ydeS	unknown
ydfD	unknown
ydfF	unknown
ydfL	unknown
ydgC	unknown
ydgG	unknown
ydgJ	unknown
ydhC	unknown
yerC	unknown
yerO	unknown
yezC	unknown
yezE	unknown
yfiF	unknown
yfiR	control of [gene\|search\|yfiS ]expression
yfiV	unknown
ygzD	unknown
yhbI	unknown
yhcF	unknown
yhdI	unknown
yhgD	unknown
yhjH	unknown
yisR	unknown
yisV	unknown
yizB	unknown
ykoM	unknown
ykvN	unknown
ykvZ	unknown
ymfC	unknown
yoaU	unknown
yobD	unknown
yobQ	unknown
yobS	unknown
yonR	unknown
yopO	unknown
yopS	unknown
yotL	unknown
yozG	unknown
ypoP	unknown
yqaF	unknown
yqaG	unknown
yraN	unknown
yrdQ	unknown
ysfB	unknown
ysmB	unknown
ytcD	unknown
ytoI	unknown
ytzE	unknown
yusT	unknown
yuzN	unknown
yvaF	unknown
yvaO	unknown
yvaV	unknown
yvbU	unknown
yvdE	probably regulation of starch and maltodextrin utilization
yvdT	unknown
yvkB	unknown
yvzC	unknown
ywbI	control of expression of the [gene\|7DA08C189F5524D4874E2F4828264AB2671A5460\|ywbH]-[gene\|2940E73F0BCAB69992BBD224402C95C2667757AD\|ywbG] operon
ywhA	unknown
ywoH	unknown
ywqM	unknown
ywzG	unknown
yxaD	unknown
yxbF	unknown
yxjO	unknown
yyaN	unknown
yybA	unknown
yybE	unknown
yydK	unknown

3.4.2.7. Control of transcription factor (other than two-component system)

Name	Function
abbA	inhibition of [protein\|E5110D9C36E8C55AFD1419987B14A53232165F20\|AbrB]
crh	control of carbon flux
cysK	biosynthesis of cysteine, control of [protein\|50930C56C27D22715620A350220E3C56ADB41020\|CymR] activity
glnA	glutamine biosynthesis, control of [protein\|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20\|TnrA] and [protein\|641C4BDD9702804642E1753A9C779E80FABB3919\|GlnR] activity
gudB	glutamate utilization, control of [protein\|87BCAE725B02860156D50E1783F6DB68510C811E\|GltC] activity
hprK	carbon catabolite repression,phosphorylation of [protein\|29B793660E4D30C0656248F3EF403FEF76FB9025\|HPr] and [protein\|A269774F2FDC94F93BA5F1360FFFE754B50383AD\|Crh] proteins at Ser46
hprT	purine salvage and interconversion, control of [gene\|4E7B9426CED372AA8A321A147116A3A589FBF20C\|ftsH] expression
immA	control of [protein\|DD1C8F3A4809785BD6A6047D39B42AB2C605E161\|ImmR] activity
mcsA	control of [protein\|908DB17A39D518E84977250C55825E77FA02E391\|CtsR] activity
mcsB	control of [protein\|908DB17A39D518E84977250C55825E77FA02E391\|CtsR] activity
nrgB	regulation of ammonium uptake
phrI	control of the transfer of the mobile genetic element ICEBs1
ptsH	PTS-dependent sugar transport and carbon catabolite repression
rapI	control of transfer of the mobile genetic element ICEBs1
rocG	arginine utilization, controls the activity of [protein\|87BCAE725B02860156D50E1783F6DB68510C811E\|GltC]
rtpA	regulation of tryptophan biosynthesis
salA	control of alkaline protease expression
sinI	control of [SW\|biofilm formation]
slrA	control of motility and biofilm formation
tilS	tRNA modification, control of [gene\|4E7B9426CED372AA8A321A147116A3A589FBF20C\|ftsH] expression
ylbF	control of [protein\|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4\|RNase Y] activity, see [SW\|Targets of the Y complex]
ymcA	control of [protein\|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4\|RNase Y] activity, see [SW\|Targets of the Y complex]
yqfL	inhibits [protein\|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636\|CcpN] activity

reviews on transcription regulation

19721087,19632156,16772031,18599813,22210308,23504016,22728391


3.4.1	Sigma factors and their control
3.4.2	Transcription factors and their control
3.4.3	Trigger enzyme
3.4.4	RNA binding regulators
3.4.5	Regulators of core metabolism
3.4.6	Transition state regulators
3.4.7	phosphorelay
3.4.8	Quorum sensing
3.4.9	Other regulators